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Abstract
The effects of alcohol–kola nut interactions on activites of whole brain glucose oxidase, glutamine synthetase, and adenylate deaminase were examined in Wistar rats. Thirty Wistar albino rats were divided into six groups. Control group (1) received a placebo (4 mL of distilled water). Groups 2–6 were treated for a 21-day period with either 10% (v/v) alcohol, kola nut, caffeine, alcohol + kola nut, or alcohol + caffeine at 50 mg per kg in a total volume of 4 mL vehicle via gastric intubation, respectively. One day after the final treatment, the whole brain was harvested and processed to examine for several biochemical parameters, including activities of glucose oxidase, adenylate deaminase, and glutamine synthetase. Results showed that alcohol–kola nut interaction decreased the activities of glucose oxidase, adenylate deaminase, and glutamine synthetase in whole brain, suggesting inhibition of glutamine synthesis, decreased energy (ATP) production, ionic transport and decreased neuronal processes. Data indicates that alcohol–kola nut or alcohol–caffeine interactions modify neuronal processes in rat brain; however, the clinical importance of this is not known.