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Abstract
An investigation was conducted to identify high-risk industries for histological subtypes of lung cancer based on a large population-based case-control study in British Columbia, Canada. Occupational histories and information on smoking and relevant covariates were collected from 14,755 male incident cancer cases. Industrial risk factors for 2998 lung cancer cases, including histological subtypes were assessed by logistic regression using other cancer cases, excluding smoking-related cancers, as controls. An excess risk of lung cancer was found among workers in mining, metal manufacturing, and electric power systems for all histological-subtypes, and construction, water transport, health services for specific histological subtypes. Industrial associations that are unique to histological subtypes of lung cancer were identified. Future research needs to focus on confirming these histological associations, and identifying the risk from key exposures found within these industries (e.g. medical radiation, electromagnetic fields, and cooking fumes).
Acknowledgements
Financial support for this project was provided by the McLaughlin foundation and PREECAN award. We gratefully acknowledge Dr. Pierre Band, Dr. Nhu Le and Raymond Fang from the BC Cancer Agency for providing the data. Dr Daniel Krewski is the NSERC/SSHRC/McLaughlin Chair in Population Health Risk Assessment at the University of Ottawa.
Notes
Note
1. During the course of this analysis, we became aware of an independent but related analysis conducted by MacArthur et al., Am. J. Med., 2009, to appear. This analysis involved somewhat different analytical methods, but reached generally similar conclusions.