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Abstract
Perfluorinated compounds have been manufactured in large quantities and used in myriad industrial processes and commercial applications. The aim of this preliminary study was to generate hypotheses with regard to differences in body burdens of perfluoroalkyl acids, among a sub-sample of participants from the New York State Angler Cohort Study, over a time interval during which no known substantial changes occurred in US manufacturing practices or commercial use. Paired serum specimens, collected from 15 subjects in 1993–1994 (time 1), and in 1995–1997 (time 2), with a minimum interval of 2.5 years, were assayed for PFDA, PFHpA, PFHxS, PFNA, PFOA, PFOS, PFOSA and PFUnDA using HPLC with ES-MS/MS. By subject, differences in concentrations between time 1 and time 2 were estimated, employing paired t-tests, correlations, and multivariable linear regression to accommodate heterogeneity in duration between specimens, and in time 1 concentrations. A statistically significant (P < 0.05) adjusted mean decrease of 0.16 ng mL−1 (18.8%) between time 1 and 2 was detected for PFNA, and an adjusted mean increase of 0.54 ng mL−1 (56.8%) was detected for PFOA. The results of this study may be indicative of short-term changes in human body burdens of PFNA and PFOA in association with local exposure sources.
Acknowledgments
This research was funded in part by the Agency for Toxic Substances and Disease Registry (ATSDR), Grant H75-ATH 298338, the Great Lakes Protection Fund, Grant RM 791-3021 and the Centers for Disease Control and Prevention (CDC) National Center for Environmental Health (NCEH), Grant U59CCU22339202. The authors would like to thank Dr. Adriana Verschoor for technical review of this manuscript.