Changes in plasma taurine concentration during a period of heroin detoxification

Abstract

Taurine is one of the most abundant sulpho-amino acids in the body. Hypertaurinemia has already been reported following different stress states. A previous study demonstrated a significant increase of serum taurine concentration in heroin addicts. Therefore, we hypothesized that taurine could be a possible biomarker of recovery during detoxification from opiates. For this purpose, 30 heroin addicts who went under the 5-day heroin detoxification process were recruited for the study. Three blood samples (5 mL each) were taken from each patient in the first, third, and fifth days. They were collected in heparinized glass tubes and after centrifuging, the plasma was separated and kept in the −20°C freezer until analysis using a previously developed HPLC method with fluorescence detection. The data were statistically analyzed using the Student t-test and ANOVA. Plasma taurine concentration in addicts was significantly more than that of the healthy controls (p < 0.0001). However, there were no changes in the plasma taurine concentration in the addicts during the 5-day study period (p > 0.05). Therefore, we can conclude that the plasma taurine concentration could not be considered as a biomarker of recovery in a 5-day detoxification period of heroin addiction.

Keywords:

• taurine
• stress
• addiction
• biomarker
• opiates
• heroine

Acknowledgments

The authors wish to thank the heroin addicts, the personnel of Razi psychiatric hospital of Tabriz, and Dr Derek Buss (PhD in Pharmacology from the school of Medicine, Cardiff University, UK) for their excellent cooperation.