Plasma lipid profiles and risk of cardiovascular disease on occupational exposure in Karimnagar

Abstract

Occupational exposure is unregulated in developing countries like India, and becoming the most common cause of disease of environmental origin. The present study was aimed to investigate the effects of occupational exposure on plasma lipid profiles, and risk of cardiovascular diseases. A total of 79 human volunteers were included in the study. Control subjects were healthy housewives of Karimnagar, India. Occupationally exposed individuals included different occupational workers like petrol station attendants, battery chargers, drivers, welders, pesticide-exposed workers, painters, and auto mechanics. These subjects were shown to be chronic occupationally-exposed for at least three years, and neither associated with any other chronic pathological conditions like hypertension or diabetes, nor under any medication other than analgesics during the month preceding the study. Subjects with excessive high or low caloric intake were excluded from the study. Total cholesterol (TC), LDL cholesterol, triglycerides (TG), VLDL cholesterol, LDL/HDL cholesterol, and TC/HDL ratio in these subjects were significantly higher than those in control subjects, whereas HDL cholesterol was not markedly affected. Blood pressure (systolic and diastolic), and other anthropometric parameters (body mass index (BMI), body fat index (BFI), body surface area (BSA)) were not significantly different between groups. Data suggest that chronic occupational exposure increases plasma lipid levels and is thereby associated with cardiovascular complications.

Keywords:

• occupational exposure
• plasma lipid profiles
• cardiovascular diseases
• anthropometric parameters

Acknowledgements

The first author is grateful to all the volunteers of Karimnagar town who have participated in this study. All the authors are thankful to Dr. G. Sreenivas Reddy, General Secretary of Vaageswari College of Pharmacy, Karimnagar for providing necessary facilities to complete this study.

Notes

Note: All the values are expressed in mean ± standard deviation; * p < 0.05 vs control.