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Toxicological & Environmental Chemistry Volume 99, 2017 - Issue 7-8: Mathematical approaches to environmental chemistry
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Mathematical approaches to environmental chemistry

Quantitative structure activity-relationships for toxicity screening of pesticide impurities for regulatory submission – practical experiences and challenges

Stefan PudenzRegulatory Consulting, Envigo (CRS) Switzerland Ltd., Füllinsdorf, SwitzerlandCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-7128-3584
ORCID Icon &
Asta Ruzgyte FrèreRegulatory Consulting, Envigo (CRS) Switzerland Ltd., Füllinsdorf, SwitzerlandORCID Iconhttp://orcid.org/0000-0002-4994-5684
ORCID Icon
Pages 1071-1077 | Received 23 Jun 2016, Accepted 21 Nov 2016, Published online: 20 Jan 2017
 
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ABSTRACT

The toxicological assessment of impurities of the technical active substance in pesticides with quantitative structure activity-relationship modelling has become an important aspect in authorisation by regulatory bodies. This paper discusses the challenges and drawbacks when predicting toxicities of impurities of technical active substances of pesticides for regulatory submission.

Acknowledgements

We are grateful to the reviewers for their constructive input.

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

1. Obtained from five-batch analysis of purity/impurity in samples provided by the manufacturer.

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