Treatment and skin decontamination of sarin intoxicated mice

Abstract

This study aimed at evaluating the efficacy of oral treatment and skin decontamination with the mineral cationic carrier in sarin-intoxicated mice. Mice were contaminated with increasing percutaneous sarin doses and decontaminated. Furthermore, the surviving mice were treated per os. The behavioral patterns of the surviving animals were monitored for 72 h, including the animals’ posture, desire for food and water, and approach and touch response. The results showed the mineral cationic carrier to be capable of efficiently decontaminating animals percutaneous poisoned with triple lethal dose. The comparison of behavioral pattern of control animals against those treated per os showed statistically significant differences. Oral treatment with mineral cationic carrier may be a detoxification tool against nerve agents’ poisoning, and this merits further research.

Keywords:

• Treatment
• mice
• mineral cationic carrier (MCC)
• sarin
• skin decontamination

Acknowledgments

The authors would like to thank Boris Subotić (Rudjer Boskovic Institute, Zagreb, Croatia) for providing the MCC preparation and Ivan Jukić (Zagreb, Croatia) for providing the chemical agent sarin. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Disclosure statement

No potential conflict of interest has been reported by the authors.