Ameliorative effects of paricalcitol against 1800-MHz mobile phone radiation-induced skin damage in rats

Abstract

This study aimed to evaluate the protective role of paricalcitol, a vitamin D analog, against hazardous effects of 1800-MHz radiofrequency (RF) radiation on the skin of male Wistar albino rats exposed one h/day for 4 weeks. The maximum specific absorption rate was calculated as 0.0042 W/kg. Superoxide dismutase and catalase activity, collagen bundle thickness, breaking force, energy, and stress were decreased, while malondialdehyde level and mast cell number were increased. The exposure to 1800-MHz RF radiation caused a reduction in skin biomechanical quality through oxidative stress and mast cell activation. The administration of paricalcitol caused a significant improvement.

Keywords:

• 1800-MHz RF
• paricalcitol
• skin
• oxidative stress

Acknowledgments

The authors thank Dr Evren Değirmenci for help in measuring skin temperature changes and M. Akın Çömelekoglu for help in drawing Figure 1.

Disclosure statement

The authors declare that there are no conflict of interest.

Additional information

Funding

This work was supported by the Research Fund of Mersin University in Turkey [grant number BAP, 2017-1-TP2-2214].