The multifunctional nano-immunoliposome design: hypothesis on a therapeutic approach for COVID-19

Abstract

The article presents a hypothesis on a co-delivery strategy to suppress or reduce infection caused by the COVID-19 virus. Co-delivery was illustrated in many diseases, and results showed that it produced a high therapeutic efficacy against disorders. We proposed an approach to suppress or reduce infection caused by the coronavirus disease 2019 via designing an intelligent nano-liposome loaded with interferon γ, interleukin 4 and small interfering RNA against vimentin. At the surface of this nanostructure, there is a matrix metallopeptidase3 substrate to provide a platform for the enzymatic function of matrix metallopeptidase3 to destroy the extracellular matrix, angiotensin-converting enzyme 2 blocker, and antibody against vimentin for targeting, trans-activator of transcription peptide, and polyethylene glycol. Due to the increasing application of nano-liposomes commercially as a drug-delivery system, it is important to consider this effective approach for the coronavirus disease 2019 treatment.

Graphical Abstract

Keywords:

• COVID-19
• nano-immunoliposome
• ACE2
• interferon
• vimentin

Acknowledgments

The authors thank the Shahrekord University of Medical Sciences.

Author contributions

All authors collected and analyzed relevant literature, then drafted the manuscript, critically revised the manuscript for content, and finally read and approved the final manuscript.

Disclosure statement

The authors report that there are no conflicts of interest.