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Eco/Toxicology

Protective effects of taurine against hepatotoxicity induced by pharmaceuticals and environmental chemicals

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Pages 56-84 | Received 22 Jan 2021, Accepted 11 Feb 2021, Published online: 11 Mar 2021
 

Abstract

The liver plays a central role in metabolism, so excessive exposure to drugs and other xenobiotics may result in hepatotoxicity. A protective effect of taurine, a conditionally essential amino acid, against hepatotoxicity induced by chemicals has been shown in vivo and in vitro. In this review, data available from such studies about the hepatoprotective effects of taurine are presented and possible mechanisms of action are discussed. The reviewed literature suggests that taurine inhibits oxidative stress and inflammation, induces conjugation of xenobiotics with bile acids, stabilizes cell membranes, controls hepatic glutathione contents, and suppresses certain cytochrome isozymes, all indicating anti-apoptotic, antioxidant, and osmoregulatory properties of taurine.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research was supported by Tarbiat Modares University and Mashhad University of Medical Sciences.

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