Prevention of toxic effects of orally administered tartrazine by crocin in Wistar rats

Abstract

Tartrazine is used in the pharmaceutical, cosmetic, and food industries worldwide, despite its many toxic effects. The therapeutic effects of crocin (50 mg/kg/day) against tartrazine-induced (500 mg/kg/day) oxidative damage in ileum and colon tissues in rats have been investigated. Malondialdehyde and total oxidant status levels elevated by tartrazine within the ileum and colon tissues were reduced with crocin treatment, while tartrazine decreased antioxidative parameters (glutathione, total antioxidant status, superoxide dismutase, and catalase) were reverted. Tartrazine-induced histopathological changes of ileum and colon tissues were ameliorated following crocin treatment. In conclusion, Tartrazine consumption elicited tissue injury via lipid peroxidation, and crocin ameliorated oxidative injury by its antioxidant and free radical scavenger properties.

Keywords:

• Tartrazine
• crocin
• oxidative stress
• malondialdehyde
• ileum
• colon

Disclosure statement

The authors declared that there is no conflict of interest.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This research was supported by Karabuk University scientific research fund (KBU-BAP-16/2-YL-093).