Subacute toxicity studies on pentachlorophenol (PCP), and the isomeric tetrachlorobenzenediols tetrachlorohydroquinone (TCH), tetrachlorocatechol (TCC), and tetrachlororesorcinol (TCR)

The toxicity of pure pentachlorophenol (PCP), tetrachlorohydroquinone (TCH), tetrachlorocatechol (TCC), and tetrachlororesorcinol (TCR), was examined in a short‐term study with female rats for 28 days. The substances were administered orally in doses of 0.2mMol/kg body wt×day, corresponding to 53.27 mg PCP, respectively 49.58 mg tetrachlorobenzenediol per kg body wt and day. The treatment had no effect on growth. Changes in relative liver weight, hematological parameters, and cell alterations in liver were only found in rats dosed with PCP.

Key words:

• Toxicity
• pentachlorophenol
• tetrachlorobenzenediol
• tetrachlorohydroquinone
• tetrachlorocatechol
• tetrachlororesorcinol