Abstract
The effects of daily administration of hexachlorocyclohexane (HCH) for 90 days on the distribution of Cu, Zn, Fe and Mn in rat tissues were investigated. The results indicated that HCH caused a significant increase in weight of liver and spleen and decrease in the weight of kidney, heart and brain. The spleen and heart demonstrated the maximum mobilization of metals. Comparing the individual trace elements, zinc appeared to be the most active element. None of the metals assayed registered change in RBC's but there was increase in Zn, Fe and Mn concentration in plasma.
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