Inhibitory effect of some biological compounds on catecholamines peroxidation

J. Kruk Department of Human Ecology, Faculty of Natural Sciences, University of Szczecin, Al. Piastów 40 b/6, Szczecin, 71–065, Poland

A. Kladna Department of Human Ecology, Faculty of Natural Sciences, University of Szczecin, Al. Piastów 40 b/6, Szczecin, 71–065, Poland

H. Y. Aboul‐Enein Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department (MBC‐03), King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh, 11211, Saudi Arabia

I. Kruk Institute of Physics, Technical University of Szczecin, Al. Piastów 17, Szczecin, 70–310, Poland

The aim of the present study was to investigate the inhibitory effect of a number of biologically important compounds on catecholamines (adrenaline, noradrenaline, dopamine) peroxidation with respect to production of reactive oxygen species, especially hydroxyl radicals. Measurements were done using a chemiluminescence technique, in presence of the Cu(II) + H₂O₂ system. From the compounds examined (some of them proved to be effective in clinical use) carnosine, myoglobin, cimetidine, methionine, captopril, α‐lipoic acid, glutathione, were strongly effective as antioxidants.

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