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Acta Radiologica Volume 29, 1988 - Issue 1
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Original Article

Intravenous injection of ioxilan, iohexol and diatrizoate

Effects on urine profiles in the rat

H. S. Thomsen Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
S. Dorph Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
T. Mygind Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
M. Sovak Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
H. Nielsen Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
H. Rygaard Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
S. Larsen Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
P. Skaarup Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
,
L. Hemmingsen Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
&
J. Holm Department of Nuclear Medicine, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; The Institute of Pathology, Københavns Amts Sygehus I Herlev, University of Copenhagen, DK-2730, Herlev, Denmark; Department of Clinical Chemistry, Centralsygehuset, DK-4800 Nykøbing FalsterDenmark; Department of Radiology S-009, University of California San Diego, La Jolla, California, 92093, USA; Biophysica Foundation, La Jolla, California, 92037, USA
 show all
Pages 131-136 | Accepted 10 Sep 1987, Published online: 04 Jan 2010
 

Abstract

Effects of intravenous ioxilan, a new third generation non-ionic contrast medium, diatrizoate, iohexol and saline on urine profiles were compared. Albumin, glucose, sodium, phosphate, and the enzymes NAG, LDH and GGT were followed in 24 normal rats over 7 days. Diatrizoate significantly affected all profile components during the first two hours. Albuminuria was significantly greater after diatrizoate than after iohexol or ioxilan, and excretion of glucose, LDH and GGT was significantly higher than after ioxilan. Both iohexol and ioxilan increased the excretion of albumin, LDH and GGT, while iohexol also significantly increased excretion of glucose and sodium. There was a greater excretion of glucose and GGT after iohexol than after ioxilan. Saline did not induce any changes. At day 7, serum sodium, urea, creatinine, and albumin were normal for all test substances, and kidney histology revealed no difference between the groups of animals. It is thus concluded that both high osmolar ionic and low osmolar non-ionic contrast media may cause temporary glomerular and tubular dysfunction in rats. In this model, the kidney is affected most by diatrizoate, less by iohexol, and least by ioxilan.

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