Osteocalcin in acute stress response: from the perspective of cardiac diseases

Abstract

Osteocalcin is an osteoblast-derived peptide mainly found in the bone matrix but also in circulation. A recent investigation suggested that osteocalcin mediated acute stress response (ASR) by inhibiting parasympathetic tone in mice and humans. We propose a hypothesis that osteocalcin is regulated by the skeleton movement and glucocorticoids, and inhibition of the parasympathetic tone by osteocalcin may indicate a therapeutic target in the treatment of acute myocardial infarction (AMI).

Keywords:

• Osteocalcin
• acute stress response (ASR)
• acute myocardial infarction (AMI)
• autonomic nervous system

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Declaration of funding

This manuscript was written independently; no company or institution supported the authors financially or by providing a professional writer.

Declaration of financial/other relationships

The authors and peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Acknowledgements

None reported.