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Abstract
Objective
Coronary heart disease (CHD) is the most common cause of death in patients with type 2 diabetes (T2DM). We aim to estimate the prevalence of CHD and cardiovascular risk factors in Chinese patients with T2DM.
Methods
A total of 66,536 inpatients with diabetes treated from 2013 to 2018 were investigated, and demographic and clinical data were collected from 30,693 patients with T2DM. Age-standardized prevalence of CHD was calculated on the basis of data from the Chinese population census in 2010. Logistic regression analysis was used to analyze the risk factors.
Results
The crude prevalence of CHD was estimated to be 23.5% and a standardized prevalence was 13.9% (16.0% in men and 11.9% in women). More than half of patients with CHD have four or more of the five traditional risk factors, much higher than the 38.96% of patients without CHD (p < .01). Multivariate regression analysis showed that diabetes duration, hypertension, smoking, underweight, overweight, obesity and hypoglycaemia were significantly associated with increased risk of CHD (all p < .05). The odds ratio of CHD in patients with three, four or five defined CHD risk factors (i.e. diabetes, hypertension, dyslipidaemia, overweight or obese, and smoking) were 2.35 (95% CI 1.81–3.04), 2.96 (95% CI 2.28–3.85) or 5.29 (95% CI 4.04–6.93), compared with diabetes patients without any other risk factors.
Conclusions
The prevalence of CHD was rather high in Chinese T2DM inpatients, and the aggregation of CHD risk factors was severe. Thus, hierarchical CHD prevention strategies based on risk factors are necessary.
Transparency
Declaration of funding
This research was supported by the National Natural Science Foundation of China (No. 81570732, Shaohua Wang; and No. 81870568, Shaohua Wang).
Declaration of financial/other relationships
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
CMRO peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Data availability statement: The data used to support the findings of this study are available from the corresponding author upon request.
Author contributions
C.W. was the main contributor to the writing of the manuscript. X.H. collected and analysed data. Z.X., Z.W. and H.S. contributed to the planning and interpretation of the research. As the corresponding author, S.W. was responsible for the overall content of this manuscript. All authors read and approved the final manuscript.
Acknowledgements
The authors would like to express our heartfelt thanks to all the participants and the staff of the information department of Zhongda Hospital affiliated to Southeast University.