Drug utilization, clinical and economic outcomes of patients with osteoarthritis of the hip and/or knee treated with long-term use of traditional NSAIDs, topical NSAIDs, and COX-2 inhibitors

Abstract

Objectives

To describe and compare baseline characteristics, healthcare and drug utilization, and negative clinical outcomes of commercially-insured patients diagnosed with OA of the hip and/or knee who initiated treatment on traditional oral NSAIDs (tNSAIDs), topical NSAIDs, or cyclooxygenase-2 inhibitors (COX-2s).

Methods

A commercial claims database (1/2012–3/2017) was used to identify patients ≥18 years old, with ≥2 diagnoses of hip and/or knee OA, and ≥90 days supply of NSAIDs. Patients were assigned to cohorts based on the type of NSAID initially prescribed and observed in the 6 months before (baseline) and 36 months after (follow-up) the date of their first NSAID prescription after the first OA diagnosis. Analyses estimated baseline demographic and clinical characteristics and follow-up period drug utilization. Logistic regressions assessed the risk of gastrointestinal (GI) and acute renal failure (ARF) events.

Results

tNSAIDs were the most frequently prescribed treatment. During the follow-up period, less than 15% of patients prescribed tNSAIDs switched to either COX-2s or topical NSAIDs and 37% of patients prescribed a COX-2 and 56% of patients prescribed a topical NSAID switched to tNSAIDs. GI and ARF events during the follow-up period ranged from 7.3–8.1% and 8.0–11.0%, respectively, across cohorts. The tNSAIDs and COX-2s cohorts had increased risk of both types of events relative to patients prescribed topical NSAIDs, controlling for other characteristics.

Conclusions

Analyses characterize the long-term real-world utilization of NSAIDs and associated outcomes for patients with OA of the hip and/or knee. Study results highlight the likelihood of switching and the risk of negative clinical outcomes associated with long-term use.

Keywords:

• Osteoarthritis
• NSAIDs
• COX-2s
• cardiovascular
• gastrointestinal
• renal events

Transparency

Declaration of funding

This study was funded by Pfizer and Eli Lilly and Company.

Declaration of financial/other relationships

Stuart Silverman is a paid consultant to Pfizer and Eli Lilly and Company in connection with this study. Brad Rice, Michaela Johnson, and Alan White are employees of the Analysis Group, who were paid consultants to Pfizer and Eli Lilly and Company for this study and development of this manuscript. Rebecca Robinson is an employee and stockholder of Eli Lilly and Company. Patricia Schepman, Craig Beck, and Birol Emir are employees of Pfizer with stock and/or stock options. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Acknowledgements

None.