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Connective Tissue Research Volume 49, 2008 - Issue 3-4
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Original

Dysregulation of Matrix Metalloproteinases and their Tissue Inhibitors by S100A4

Renate Elenjord Department of Pharmacy, University of Tromsø, Tromsø, Norway
,
Hilde Ljones Department of Pharmacy, University of Tromsø, Tromsø, Norway
,
Elisabeth Sundkvist Department of Pharmacy, University of Tromsø, Tromsø, Norway
,
Thrina Loennechen Department of Pharmacy, University of Tromsø, Tromsø, Norway
&
Jan Olof Winberg Department of Medical Biology, University of Tromsø, Tromsø, Norway
Pages 185-188 | Published online: 06 Aug 2009
 
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Abstract

The S100A4 protein as well as the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are associated with diseases such as arthritis and cancer. This mini review focuses on in vitro and in vivo studies indicating S100A4 involvement in regulation of MMPs and TIMPs, and the biological and pathobiological consequences of this regulation.

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