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Connective Tissue Research Volume 49, 2008 - Issue 3-4
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Original

Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

Paraskevi Heldin Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Uppsala, Sweden
,
Eugenia Karousou Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Uppsala, Sweden
,
Berit Bernert Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Uppsala, Sweden
,
Helena Porsch Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Uppsala, Sweden
,
Koichi Nishitsuka Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Uppsala, Sweden
&
Spyros S. Skandalis Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Uppsala, Sweden
Pages 215-218 | Published online: 06 Aug 2009
 
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Abstract

Hyaluronan is an apparently simple polysaccharide that is responsible for tissue hydration but also stimulates cell proliferation, migration, and differentiation via binding to cell surface receptors, such as CD44. The amounts of hyaluronan increase during inflammation and tumorigenesis through the action of chemokines and growth factors. This review discusses some of the evidence that hyaluronan-CD44 complexes trigger signaling cascades that modulate inflammation and tumor progression.

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