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Connective Tissue Research Volume 49, 2008 - Issue 3-4
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Original

Hyaluronan, CD44, and Cyclooxygenase-2 in Colon Cancer

Suniti Misra Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina, USA
,
Vincent C. Hascall Department of Biomedical Engineering, Cleveland, Ohio, USA
,
Franklin G. Berger Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA
,
Roger R. Markwald Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina, USA
&
Shibnath Ghatak Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina, USA
Pages 219-224 | Published online: 06 Aug 2009
 
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Abstract

Carcinomas arising from colon epithelia develop or progress in a stromal microenvironment that is elevated in hyaluronan; interactions between elevated hyaluronan and the CD44 receptors on epithelial tumor cells activate an HA-receptor tyrosine kinase-mediated cell survival pathway. In this review we provide evidence that the hyaluronan-ErbB2-PI3kinase/AKT-ß-catenin-COX-2 signaling axis leads to intestinal epithelial and colon tumor cell division and proliferation. This review includes a summary of the authors work over the past years as well as citations of specific reviews related to role of hyaluronan in the pathogenesis of colon cancer.

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