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Connective Tissue Research Volume 49, 2008 - Issue 3-4
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Original

Tissue-Specific shRNA Delivery: A Novel Approach for Gene Therapy in Cancer

Shilenath Ghatak Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA
,
Viacent C. Hascall Department of Biomedical Engineering/ND20, Cleveland Clinic, Cleveland, Ohio, USA
,
Franklin G. Berger Department of Biological Sciences, USC at Columbia, Columbia, South Carolina, USA
,
Maria M. O. Penas Department of Biological Sciences, USC at Columbia, Columbia, South Carolina, USA
,
Celestia Davis Department of Biological Sciences, USC at Columbia, Columbia, South Carolina, USA
,
Esmaiel Jabari Department of Chemical Engineering, USC at Columbia, South Carolina, USA
,
Xuezhong He Department of Chemical Engineering, USC at Columbia, South Carolina, USA
,
James S. Norris Department of Microbiology and Immunology, MUSC, Charleston, South Carolina, USA
,
Yujing Dang Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA
,
Roger R. Markwald Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA
&
Suniti Misra Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA
 show all
Pages 265-269 | Published online: 06 Aug 2009
 
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Abstract

A novel tissue-specific shRNA delivery system has been developed using cre-lox technology. Conditionally silenced pSico vector containing oligonucleotides of CD44shRNA and tissue-specific promoter-driven Cre-recombinase expression vector are packaged into transferrin-coated nanoparticles that can deliver shRNA into specific tumors. This system has strong potential in cancer therapy.

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