Abstract
Tissue engineering is an emerging scientific approach that may offer alternative pathways for managing tissue degeneration. The use of cellular and acellular matrix in combination with cells and/or growth factors is one approach currently being explored in the management of rotator cuff disease. Interestingly, the integration of gene therapy with this technique introduces a new dimension to treatment options. The scope of this article is to present an overview of the current tissue engineering in vivo methods being clinically investigated in rotator cuff disease.