Recent progress in the biology and physiology of BMP-8a

ABSTRACT

Purpose

BMP-8a is a member of bone morphogenetic proteins (BMPs) and plays a regulatory role in human growth and development as a transcription regulator. This review aims to summarize the current research on the impact and mechanism of BMP-8a in female and male reproduction, formation and eruption of teeth, bone and cartilage development, tissue differentiation, disease occurrence, progression and prognosis.

Methods

The phrases “BMP-8a,” “BMPs,” “regulator,” “mechanism,” “osteoblast,” “cartilage,” “cancer,” “disease,” and “inflammation” were searched in the PubMed database. The abstracts were evaluated, and a series of original publications and reviews were examined.

Results

According to the search, BMP-8a affects the development of the uterus by inhibiting luteinization and plays an important role in late spermatogenesis. It is highly expressed in osteogenesis and differentially expressed in chondrogenesis. Furthermore, BMP-8a has a significant impact on the occurrence, development and prognosis of various diseases.

Conclusions

BMP-8a regulates important factors and pathways, such as SMAD2/3 and SMAD1/5/8, to promote or inhibit the developmental processes of human reproductive organs. BMP-8a is also a member of the BMP family of proteins that regulates chondrogenesis and osteogenesis. In addition to its osteoinductive capabilities, BMP-8a is involved in the progression of diverse cancers.

KEYWORDS:

• BMP-8a
• BMP signaling pathway
• osteoblast
• reproductive system
• disease

Acknowledgments

This work was supported by the Undergraduate Scientific Research and Innovation Experiment Project in Chongqing Medical University [Grant No. SRIEP202158].

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The work was supported by the Undergraduate Scientific Research and Innovation Experiment Project in Chongqing Medical University [SRIEP202158].