Abnormal regional cerebral blood flow in primary antiphospholipid antibody syndrome patients with normal magnetic resonance imaging findings

J. J. H. Chen Section of Rheumatology, Department of Internal Medicine, China Medical College Hospital, Taichung, Department of Nuclear Medicine, Far Eastern Memorial Hospital, Institute of Biomedical Engineering, College of Electrical Engineering, National Taiwan University, Taipei, Department of Medical Research, Chi-Mei Medical Center, Tainan, School of Medicine, National Defense Medical Center, Taipei, Departments of Nuclear Medicine and Medical Research, China Medical College Hospital, Taichung, Taiwan

Y. C. Shiau Section of Rheumatology, Department of Internal Medicine, China Medical College Hospital, Taichung, Department of Nuclear Medicine, Far Eastern Memorial Hospital, Institute of Biomedical Engineering, College of Electrical Engineering, National Taiwan University, Taipei, Department of Medical Research, Chi-Mei Medical Center, Tainan, School of Medicine, National Defense Medical Center, Taipei, Departments of Nuclear Medicine and Medical Research, China Medical College Hospital, Taichung, Taiwan

J. J. Wang Section of Rheumatology, Department of Internal Medicine, China Medical College Hospital, Taichung, Department of Nuclear Medicine, Far Eastern Memorial Hospital, Institute of Biomedical Engineering, College of Electrical Engineering, National Taiwan University, Taipei, Department of Medical Research, Chi-Mei Medical Center, Tainan, School of Medicine, National Defense Medical Center, Taipei, Departments of Nuclear Medicine and Medical Research, China Medical College Hospital, Taichung, Taiwan

S. T. Ho Section of Rheumatology, Department of Internal Medicine, China Medical College Hospital, Taichung, Department of Nuclear Medicine, Far Eastern Memorial Hospital, Institute of Biomedical Engineering, College of Electrical Engineering, National Taiwan University, Taipei, Department of Medical Research, Chi-Mei Medical Center, Tainan, School of Medicine, National Defense Medical Center, Taipei, Departments of Nuclear Medicine and Medical Research, China Medical College Hospital, Taichung, Taiwan

A. Kao Section of Rheumatology, Department of Internal Medicine, China Medical College Hospital, Taichung, Department of Nuclear Medicine, Far Eastern Memorial Hospital, Institute of Biomedical Engineering, College of Electrical Engineering, National Taiwan University, Taipei, Department of Medical Research, Chi-Mei Medical Center, Tainan, School of Medicine, National Defense Medical Center, Taipei, Departments of Nuclear Medicine and Medical Research, China Medical College Hospital, Taichung, Taiwan

Abstract

Technetium-99m ethyl cysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) was used to detect abnormal regional cerebral blood flow (rCBF) in primary antiphospholipid antibody syndrome (PAPS) patients. The patients had mild neuropsychiatric manifestations and normal brain magnetic resonance imaging (MRI) findings in this preliminary study. Fifteen such female PAPS patients were examined with Tc-99m ECD brain SPECT in order to evaluate the rCBF. In addition, serum anti-cardiolipin antibodies (ACA) and lupus anticoagulant (LA) were simultaneously measured for comparison. Results: (a) Tc-99m ECD brain SPECT revealed hypoperfusion brain lesions in 12 (80%) of the PAPS patients. Pariental lobes were the most commonly involved areas. (b) 11 (73%) and 9 (60%) cases had positive ACA and positive LA, respectively. In addition, ACA and LA results were correlated to the Tc-99m ECD brain SPECT findings. Tc-99m ECD brain SPECT is a sensitive tool for detecting abnormal rCBF in PAPS patients with mild neuropsychiatric manifestations and normal brain MRI findings.

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Abnormal regional cerebral blood flow in primary antiphospholipid antibody syndrome patients with normal magnetic resonance imaging findings

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Abnormal regional cerebral blood flow in primary antiphospholipid antibody syndrome patients with normal magnetic resonance imaging findings

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