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Abstract
Objective: The incidence of foetal loss and/or adverse foetal outcomes, including congenital heart block (CHB), has been investigated in mothers with anti‐SSA antibody detected by immunodiffusion or counter‐immunoelectrophoresis methods. We investigated the relationship between several serum parameters (such as autoantibodies and immunoglobulins) and foetal loss in patients with anti‐SSA antibody, measured by enzyme‐linked immunosorbent assay (ELISA).
Material and methods: Thirty‐seven women who showed positivity for anti‐SSA antibody and had a history of pregnancy were included in this study. Immunoglobulins and several autoantibodies were assayed by routine laboratory methods at our hospital.
Results: Our data indicated that immunoglobulin E (IgE) levels were significantly higher in the anti‐SSA antibody positive women with foetal loss than in those without, and that a strong positive correlation between IgE and anti‐SSA antibody levels was observed in the former group, but not in the latter.
Conclusion: The serum IgE level seems to be an important factor in the occurrence of foetal loss in mothers with anti‐SSA antibody detected by ELISA.