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A rare association of ankylosing spondylitis (AS) and systemic sclerosis (SSc) is reported in a Brazilian Mestizo patient presenting a human leucocyte antigen (HLA) genotype that included HLA SSc‐susceptibility genes previously reported in different ethnic groups and HLA‐B27 associated with AS. The underlying genetic background supporting the full expression of both SSc‐ and AS‐susceptibility alleles and the pertinent literature are discussed.
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