The effect of endostatin evaluated in an experimental animal model of collagen‐induced arthritis

Abstract

Objective: To investigate the arthritis‐inhibiting effect of endostatin, a potent angiogenesis inhibitor, on type II collagen‐induced arthritis (CIA).

Methods: In an experimental system of prophylactic administration, endostatin was administered once daily at 1 mg/kg/day or 10 mg/kg/day for 2 weeks from before the onset of arthritis. In the experimental system of therapeutic administration, mice with an arthritis score of 1 to 3 were administered endostatin once daily at 10 mg/kg. In the experimental system of continuous administration, endostatin was administered using an osmotic pump capable of continuously administering a calculated dose of 1 mg/kg/day for 2 weeks.

Results: Arthritis scores were lower in a dose‐dependent manner in the prophylactic administration group than in the control group. Arthritis scores were lower in the therapeutic administration group than in the control group. Compared with the once‐daily dosage regimen, the administration of endostatin by an osmotic pump achieved a similar arthritis‐inhibiting effect at one‐tenth of the dose.

Conclusion: Both prophylactic and therapeutic administration of endostatin inhibited type II CIA in mice. The administration method using an osmotic pump is useful.