Electrochemical DNA Biosensors Applicable to the Study of Interactions Between DNA and DNA Intercalators

Ioanna Ch. Gherghi Analytical Chemistry Laboratory Department of Chemical Engineering Aristotle University of Thessaloniki 54124 Thessaloniki Greece

Stella Th. Girousi Analytical Chemistry Laboratory Department of Chemistry Aristotle University of Thessaloniki 54124 Thessaloniki Greece

Anastasia A. Pantazaki Biochemistry Laboratory Department of Chemistry Aristotle University of Thessaloniki 54124 Thessaloniki Greece

Anastasios N. Voulgaropoulos Analytical Chemistry Laboratory Department of Chemistry Aristotle University of Thessaloniki 54124 Thessaloniki Greece

Roxani Tzimou-Tsitouridou Analytical Chemistry Laboratory Department of Chemical Engineering Aristotle University of Thessaloniki 54124 Thessaloniki Greece

Abstract

Electrochemical DNA biosensors, based either on carbon paste electrode (CPE) or hanging mercury drop electrode (HMDE) were prepared. These biosensors were used in the study of interaction between double stranded DNA (dsDNA) and single stranded DNA (ssDNA) and acridine orange, a well known DNA intercalator. The different electrochemical behaviors were compared in the article.

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Electrochemical DNA Biosensors Applicable to the Study of Interactions Between DNA and DNA Intercalators

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Electrochemical DNA Biosensors Applicable to the Study of Interactions Between DNA and DNA Intercalators

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