Application of Metronidazole detection by antibiotic ampicillin sodium based-carbon quantum dots

ABSTRACT

Metronidazole was traced by a new antibiotic ampicillin sodium based-carbon quantum dots (AMP N-CDs) according to fluorescence quenching mechanism. It had been found in the experiment that through dual effects of static quenching and internal filtration, the fluorescence of AMP N-CDs could be quenched by Metronidazole. Based on this phenomenon, we had established a fluorometric method to detect Metronidazole in water samples with fluorescent CDs. Metronidazole concentration showed good linear relationship with fluorescence quenching efficiency in the range of 20–100 μM (R = 0.9919) and the limit of detection (LOD) was 65.2 nM. Through these results, the AMP N-CDs was successfully used to detect Metronidazole in real samples. It provided a new insight on the bioimaging application and environmental pollutants detection.

KEYWORDS:

• Metronidazole
• AMP N-CDs
• fluorescence quenching
• pollutants
• detection

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was financially funded by Guizhou Provincial Department of education Youth Science and technology growth project (KY[2018]396 and KY[2018]402); The open fund of Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University (KY[2018]471); Bijie science and technology support project ([2016]21); Natural science research project of Guizhou Education Department (KY[2018]009).