N’-(4-(diethylamino)-2-hydroxybenzylidene) isonicotinohydrazide based chemosensor for nanomolar detection of Ni(II) ion

ABSTRACT

A novel Schiff base, N’-(4-(diethylamino)-2-hydroxybenzylidene) isonicotinohydrazide (S1) was synthesised by the condensation reaction between isonicotinohydrazide and 4-(diethylamino)-2-hydroxybenzaldehyde. The chemo-sensing behaviour of S1 towards Ni²⁺ was investigated and confirmed that the S1 exhibited fair selectivity and sensitivity. Furthermore, it was noted that there was no significant effect of co-existing cations and anions on the detection of Ni²⁺. The complexation ratio of S1 and Ni²⁺ was confirmed as 1:1 with Jobs continuous variation method and two isosbestic points on absorption titration further supported by DFT calculations. The binding constant (Kb) for S1+Ni²⁺ was calculated as 22,769 M⁻¹ and 22,134 M⁻¹. Moreover, the obtained limit of detection (LOD) for Ni²⁺ was found to be 375 nM. Finally, chemosensing applications of S1 as a paper test strip kit in the environmental monitoring assessment laboratory for the recovery of Ni²⁺ from real water samples were successfully designed and evaluated.

KEYWORDS:

• N’-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
• recognition behaviours
• complexation
• binding constant
• paper test strip kit

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No potential conflict of interest was reported by the author(s).

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Funding

Taif University Researchers Supporting Project Number (TURSP-2020/04), Taif University, Taif, Saudi Arabia