Dissipation, terminal residue and dietary risk assessment of flonicamid in cabbage

ABSTRACT

To investigate the dissipation, terminal residues, and dietary exposure risk of flonicamid, a field trial was conducted in China, and cabbage samples were determined by modified QuEChERS pretreatment and high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The method showed good linearity (R² ≥ 0.99), the mean recoveries ranged from 97% to 103%, with the relative standard deviation (RSD) less than 1.5%, and the matrix effect (ME) was 5%. The field trial showed that the dissipation of flonicamid in Shanxi conformed to the first-order kinetic equation with a half-life of 2.2 days. The terminal residue results showed that the residues of flonicamid in cabbage were all lower than 0.12 mg/kg. The hazard quotient (HQ) and risk quotient (RQ) were applied to dietary exposure risk assessment based on terminal residue and toxicology data. The HQ of different populations ranged from 0.17 to 0.37, and the RQ was 81.4%, indicating low risk of dietary intake of flonicamid in cabbage.

KEYWORDS:

• Dissipation
• terminal residues
• dietary exposure risk
• flonicamid

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/03067319.2022.2155050

Additional information

Funding

This research was funded by Shanxi Basic Research Program [202103021223149] and Shanxi Agricultural University Doctoral Start-up Fund [2021BQ127].