Determination of manganese(II) using adapalene as a novel chromogenic reagent

ABSTRACT

This study was focused on testing and evaluating the adapalene drug as a novel and selective chromogenic reagent for estimating the manganese in biological (blood plasma), pharmaceutical (syrup) and drinking water samples. The limit of detection and quantification were 0.0448 and 0.1492 μg mL⁻¹, respectively. The effective molar absorptivity (ε) was 2.0297 × 10⁴ L.mol⁻¹.cm⁻¹. The method’s sensitivity was 4.2786 × 10⁻⁴ μg cm⁻² without interference with the common ions. The results demonstrated that the stability constant of the [Mn(II) – ADP] complex was 3.7238 × 10⁷. An excellent and perfect recovery percentage of manganese(II) was achieved in tested samples, which ranged from (98–100%), (99–105%), and (97–101%) in blood plasma, medicated syrup and drinking water, respectively. Moreover, the developed method was validated by the reference ICP-OES method. The results revealed perfect compatibility between the results obtained by the developed and ICP-OES method.

KEYWORDS:

• Adapalene
• blood plasma
• drinking water
• manganese
• pharmaceutical sample
• UV-VIS spectroscop

Disclosure statement

No potential conflict of interest was reported by the author(s).