The relativity analysis of hypoxia inducible factor-1α in pulmonary arterial hypertension (ascites syndrome) in broilers: a review

ABSTRACT

Ascites syndrome (AS) in broiler chickens, also known as pulmonary arterial hypertension (PAH), is a significant disease in the poultry industry. It is a nutritional metabolic disease that is closely associated with hypoxia-inducible factors and rapid growth. The rise in pulmonary artery pressure is a crucial characteristic of AS and is instrumental in its development. Hypoxia-inducible factor 1α (HIF-1α) is an active subunit of a key transcription factor in the oxygen-sensing pathway. HIF-1α plays a vital role in oxygen homeostasis and the development of pulmonary hypertension. Studying the effects of HIF-1α on pulmonary hypertension in humans or mammals, as well as ascites in broilers, can help us understand the pathogenesis of AS. Therefore, this review aims to (1) summarize the mechanism of HIF-1α in the development of pulmonary hypertension, (2) provide theoretical significance in explaining the mechanism of HIF-1α in the development of pulmonary arterial hypertension (ascites syndrome) in broilers, and (3) establish the correlation between HIF-1α and pulmonary arterial hypertension (ascites syndrome) in broilers.

HIGHLIGHTS

• Explains the hypoxic mechanism of HIF-1α.

• Linking HIF-1α to pulmonary hypertension in broilers.

• Explains the role of microRNAs in pulmonary arterial hypertension in broilers.

KEYWORDS:

• Hypoxia inducible factor-1α (HIF-1α)
• chronic hypoxia
• ascites syndrome (AS) in broiler
• pulmonary arterial hypertension (PAH)
• microRNAs, mechanism

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Additional information

Funding

This project has received funding from the National Natural Science Foundation of China Regional Science Foundation Project [No. 31960723 Beijing, P.R. China] awarded to PL, the Natural Science Foundation of Jiangxi Province Project grant [No. 20224BAB205033] awarded to PL.