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Research Article

Pathogenicity of duck circovirus and novel goose parvovirus co-infection in SPF ducks

Yudong Zhu1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.Correspondence[email protected] [email protected]
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Qiong Wu1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.Correspondence[email protected] [email protected]
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Mian Wu1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Dalin He1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Bingrong Wu1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Mingtian Mao1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Wentao Tang1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Jiake Li1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Caiqi Wang1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Hui Zhao1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Yafei Qin1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.
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Youxiang Diao1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.Correspondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-7792-9155
ORCID Icon &
Yi Tang1 College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai’an, Shandong Province271018, China;;2 Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai’an, Shandong271018, China;;3 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai’an, Shandong271018, China.Correspondence[email protected] [email protected]
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Accepted author version posted online: 22 Jul 2024
 
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Accepted author version

Abstract

Duck circovirus (DuCV) is one of the most prevalent infectious viruses in the duck industry in China. Although the clinical signs vary, it often causes immunosuppression in the host and leads to secondary infection with other pathogens. Novel goose parvovirus (NGPV) mainly infects ducks and causes short beak and dwarfism syndrome (SBDS) in ducks. However, the incidence of infection in ducks has increased in recent years, and the phenomenon of mixed infection with DuCV is common, resulting in more severe clinical morbidity. However, there are no systematic study evaluating the presence of mixed infections. In order to investigate the synergistic pathogenicity of DuCV and NGPV co-infection in SPF ducks, a comparative experiment between DuCV and NGPV co-infection and mono-infection animal models was established. The results showed that the clinical signs of short beak, dwarfism and immunosuppression were more obvious in DuCV and NGPV co-infected ducks; the tissue damage of target organs was more serious; and the viral titer of organs and cloacal swabs were more significant compared with those of SPF ducks infected with only one virus. The results indicated that co-infection with DuCV and NGPV could promote viral replication and cause more severe tissue damage and immunosuppression than single virus infection. The present study reveals that the co-infection of NGPV and DuCV has a synergistic pathogenic effect from the aspect of pathogenicity, and the conclusions drawn not only clarify the direction of the subsequent research on the mechanism of co-infection of NGPV and DuCV, but also provide a scientific basis for the research on the co-infection of immunosuppressive diseases and other diseases.

Disclaimer

As a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.

Acknowledgement

The Innovation Leading Team Program of Guangzhou City (202009020009). China Agriculture Research System of MOF and MARA (CARS-42-19). Key Research and Development Program of Shandong Province (2022CXPT005-01-03).

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationship that could be construed as a potential conflict of interest.

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