SYNTHESIS OF α-(DIMETHYLPHOSPHINYL-METHYLENOXY)-ALKAN-ω-OLS AND α, ω-BIS(DIMETHYLPHOSPHINYL-METHYLENOXY) ALKANES

Abstract

The Williamson reaction is applied in the preparation of new tertiary phosphine oxides i.e. α-(dimethyl-phosphinylmethylenoxy) alkan-ω-ols (I) and α,ω-bis(dimethylphosphinylmethylenoxy)alkanes (II) from dimethyl-chloromethyl-phosphine oxide (DMPO) and aliphatic sodium glycolates. It is established that the two types of products are simultaneously formed. Their ratio depends on the DMPO: glycol: sodium ratio. Thus, the excess of DMPO and sodium affords mainly α,ω-bis(dimethylphosphinylmethylenoxy)-alkanes, while their use in 1.1:1:1.1 ratio affords I and II in comparative yields.