Identification, isolation, characterization, and synthesis of impurities of pesticide spirotetramat

Abstract

Research work featured in this article describes the impurity profile of spirotetramat, a widely used broad-spectrum pesticide targeting acetyl-CoA carboxylase. Technical grade spirotetramat from four different sources were analyzed and compared with commercial Movento using UPLC-MS. Seven potential impurities were detected and six of them except for the trans-isomer of spirotetramat were subsequently isolated using preparative HPLC. All impurities were characterized mainly by MS and NMR spectroscopy and their structures were further confirmed by chemical synthesis. The formation of the impurities was described in this report as well.

Keywords:

• Spirotetramat
• Movento
• impurities
• characterization
• synthesis
• UPLC-MS

Acknowledgements

The authors would like to thank Prof. Qing Jiang for consistent support and help.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article and its Supplementary Materials.