Metabolism of ß‐hexachlorocyclohexane‐¹⁴C in rats following low dosing in the daily diet

Abstract

ß‐Hexachlorocyclohexane‐ ¹⁴C (1.5 ppm) was administered in the diet to rats for one week. During the elimination phase three therapeutic agents were fed to enhance the clearance. Renal and fecal excreted radioactive products were collected for 8 weeks and extracted. Although significant differences in the total excreted amount of radioactivity were registered between controls and treated rats, there were no quantitative differences in the extractability of the excreta and no differences in the chemical nature of metabolites found.

Radioactivity in urine consisted to 100% of conversion products, about 30% of which were unextractable residues. In the organic soluble fraction the 2, 4, 6‐trichlorophenol was the major metabolite in urine and the only metabolite detected in feces. Minor conversion products of ß‐HCH in urine were a trichlorohydroxyme‐thoxybenzene, a dichlorophenol and a trace of a tetrachlorocyclo‐hexane‐isomer.

Key words:

• ß‐hexachlorocyclohexane‐ ¹⁴C
• rats
• metabolites