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Drug Metabolism Reviews Volume 38, 2006 - Issue 3
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Research Article

Human ABC Transporter ABCG2 in Xenobiotic Protection and Redox Biology

Kanako Wakabayashi Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology, Yokohama, Japan
,
Ai Tamura Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology, Yokohama, Japan
,
Hikaru Saito Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology, Yokohama, Japan
,
Yuko Onishi Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology, Yokohama, Japan
&
Toshihisa Ishikawa Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology, Yokohama, Japan
Pages 371-391 | Published online: 09 Oct 2008
 
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Abstract

Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is regarded as a member of the phase III system of xenobiotic metabolism. This efflux pump is suggested to be responsible for protecting the body from toxic xenobiotics and for removing toxic metabolites. The aim of this review article is to address new aspects of ABCG2 related to redox biology, namely the posttranslational modification (intra- and intermolecular disulfide bond formation) of ABCG2 protein and the transport of porphyrin and chlorophyll metabolites, as well as the high-speed screening and QSAR analysis method to evaluate ABCG2–drug interactions.

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