Subject Index
5-dihydrofuran-2-one, 171
ABCB1, 190
Absorption, 70, 151
Adipose Tissue, 135
Analytical, 68, 100, 156, 169, 171,172, 173, 178, 198, 213
Andrographolide, 83
Antifungal, 171
Antipsychotics, 194
Antipsyhotics, 193
Antitumor Agents, 90
Asbestos, 200
Aspirin Ticlopidine Rats, 120
Atorvastatin, 190
Azoreductase, 187
Bile Acids, 204
Bilirubin, 228
Bioavailability, 70, 71, 72, 73, 149, 150, 151, 152, 174, 183, 208, 236, 240
Blood Brain Barrier, 210
Carcinogenesis, 66
Cholestatic Hepatoxicity, 144
Clearance Prediction, 74, 75, 78, 79, 95, 102, 106, 116, 149, 176, 188
Conjugation Reactions and Enzymes, 62, 63, 77, 79, 80, 92, 93, 97, 139, 179
Cryopreservation, 124
CYP3A4*18, 195
Cytochrome P450, 53, 59, 60, 65, 78, 82, 84, 85, 86, 87, 90, 91, 92, 93, 103, 110, 112, 113, 116, 117, 121, 122, 123, 125, 124, 126, 129, 132, 135, 139, 140, 141, 145, 147, 150, 153, 154, 178, 182, 189, 193, 195, 197, 198, 201, 202, 235
Cytoprotection, 160
Depression, 211
Diabetes, 118, 204
Differences in Metabolism (species, gender, age, diseases), 77, 80, 88, 92, 93, 94, 95, 97, 152, 162, 173, 200
Disposition, 56, 57, 61, 69, 80, 94, 100, 108, 119, 151, 156, 162, 170, 171, 174, 181, 184, 185, 191, 205, 206, 216, 223, 227
Drug Absorption, 109
Drug Discovery and Development, 60, 71, 72, 74, 75, 77, 89, 90, 101, 102, 103, 104, 108, 109, 110, 121, 141, 148, 153, 154, 157, 162, 169, 173, 175, 176, 185, 186, 204, 205, 209, 212, 216, 218, 223
Drug Interaction, 57, 60, 83, 84, 85, 99, 111, 114, 115, 117, 118, 119, 121, 123, 126, 132, 144, 146, 208, 212, 216, 221, 228, 234
Drug Resistance, 233
Efficacyof Therapy, 197
Efflux, 238
Energy Metabolism, 167
Enzyme Induction, 82, 88, 91, 113, 121, 122, 123, 124, 125, 126, 127, 135, 138, 140, 145, 147, 162, 163, 182, 212
Enzyme Inhibition/Inactivation, 83, 84, 85, 104, 107, 112, 116, 117, 130, 153, 163, 182
Enzyme Kinetic Profiling, 75, 176
Extrahepatic metabolism, 65, 122, 135, 174, 180, 239
First-pass Metabolism, 69
Flubendazole, 96
Fluvoxamine, 116
Fraction Absorbed, 236
Garlic & Onion, 160
Gene Expression and Regulation, 53, 66, 89, 91, 125, 136, 138, 215, 218, 219, 220, 221, 231, 232, 233, 235
Genetic Polymorphism, 201
Genomics/Metabonomics/Proteomics, 66, 138, 139, 154, 196
Glutathione S-Transferase (GST), 87, 133
Gut Flora, 181
Hematotoxicology, 148
Hepatocytes, 64, 74, 83, 88, 89, 103, 106, 115, 123, 124, 125, 127, 126, 136, 140, 142, 144, 147, 154, 155, 160, 167, 169, 175, 205, 214, 217, 220, 221, 228, 234, 238
Herb-drug Interaction, 159
High Throughput Techniques, 67, 91, 106, 132, 149, 153, 156, 169, 212
HL-60,Boron,MTT,Neutral Red, 157
HPLC-PDA-MS, 3-(4-bromophenyl)-5-acetoxymethyl-2, 171
Human ADME Radiotracer Study, 184
Human ADME study, 178
Human Embryonic Stem Cells, 141
Hypericin, 211
In Silico, 60, 72, 78, 86, 107, 149, 151, 152, 188, 236, 237
In Vitro - In Vivo Scaling, 74
In Vitro Techniques, 57, 58, 61, 73, 74, 77, 84, 104, 106, 107, 110, 114, 117, 118, 122, 124, 125, 126, 127, 132, 133, 137, 145, 148, 149, 153, 154, 155, 156, 157, 159, 161, 165, 166, 169, 216, 217, 221, 228, 234, 238, 240
Inhaled dose ADME, 100
Intelligent Software, 67
Intestinal First-pass Metabolism, 62, 134
JNK, SP600125, 147
Leflunomide, 59
Malaria, 63
Mechanisms of Xenobiotic Toxicities, 58, 66, 82, 89, 101, 105, 133, 136, 155, 157, 159, 161, 163, 164, 165, 166, 172, 186, 200
Metabolic Profiling, 55, 67, 94, 96, 168, 170, 171, 172, 173, 175, 178, 181, 182, 184, 185
Metabolism, 55, 67, 75, 77, 80, 83, 86, 90, 94, 96, 106, 110, 113, 116, 132, 141, 146, 147, 150, 162, 172, 173, 174, 175, 180, 181, 182, 183, 184, 185, 186, 202
Methotrexate, 56
Mice, 211
Monocytes, 155
Nephrotoxicity, 161
Non-P450 Phase I Enzymes, 55, 92, 93, 188, 189
NQO1, 189
OATP, 231
OATP1B1, 214
Omeprazole, 208
P-glycoprotein, 119, 190
P-gp Inhibition, 114
Pharmacodynamics, 204
Pharmacogenetics, 59, 107, 191, 193, 194, 195, 198, 200, 201, 202, 203, 215
Pharmacokinetics, 230
Pharmacokinetics and Pharmacodynamics, 56, 57, 59, 73, 96, 99, 133, 146, 151, 152, 179, 183, 190, 191, 193, 195, 204, 206, 227, 230, 237
Phenprocoumon, 191
Physiological Modeling, 205
Piceatannol, 179
Polymorphism, 192
Pregnancy, 230
Probiotics, 180
Protein Binding, 158
Rat, 230
Reactive Intermediate, 175
Reactive Metabolites, 172
Receptor Occupancy, 213
Receptors/Nuclear Receptors, 65, 66, 107, 121, 137, 136, 139, 208, 213
Renal Impairment, 207
Risk Assessment, 199
Sheep, 96
Simvastatin, 190
St. John's Wort, 113, 211
Stereoselective Metabolism, 96, 178
Stereospecific Analysis, 68
Transporters, 57, 64, 65, 69, 71, 114, 115, 119, 122, 134, 137, 141, 142, 143, 144, 150, 152, 190, 192, 194, 196, 203, 205, 206, 214, 217, 219, 220, 221, 222, 225, 226, 227, 228, 231, 234, 235, 236, 237, 240
UDP glucuronosyltransferases (UGT), 188