Terms Index
96-well Protein Precipitation, 337
ABCB1, 327
Active metabolite, 286
Adenosine Analog, 373
Allosterism, 101, 137
Amlodipine Camsylate, 344
Analytical, 60, 70, 71, 72, 73, 75, 76, 77, 107, 133, 134, 161, 168, 175, 183, 197, 227, 229, 231, 234, 269, 291, 297, 299, 310, 348, 338, 359, 380
Animal Species, 311
Antiparasitic, 82
BCLEAR®, 239
Bile acids, 105
Bilirubin, 382
Bioactivation, 287, 306
Bioavailability, 70, 79, 80, 81, 82, 89, 135, 141, 156, 171, 172, 186, 213, 242, 343, 353, 366, 370, 372, 378, 390
Biomarkers, 60
Biotransformation, 299
Bupropion, 207
Caco-2, 238, 304
Calcein assay, 376
Cardiotoxicity, 166
Cefepime-L-carnitine interaction, 181
Children, 96
Circadian Rhythm, 65
Circadian Toxicology, 148
Citral, 207
Clearance prediction, 83, 84, 86, 87, 90, 98, 101, 144, 146, 158, 171, 188, 228, 233, 240, 243, 239, 343, 280, 326, 363
Clinical Pharmacokinetics, 160
Clozapine and 4-ethylphenol, 274
CNS penetration, 152
Conjugation reactions and enzymes, 59,89, 93, 92, 95, 96, 97, 159, 162, 201, 249, 258, 279, 291, 306, 309, 316, 334, 336, 382, 387
Constitutive Androstane Receptor, 355, 356
Cooperative effect, 109
Coumarin, 231
Covalent Binding, 257
CPM, 231
CYP2B6, 207
CYP2D6, 139
CYP2E1 X-ray structure, 140
CYP2J2, 294
CYP3A, 327
Cytochrome b5, 138
Cytochrome P450, 57, 60, 63, 64, 65, 67, 88, 99, 100, 103, 104, 105, 107, 108, 109, 111, 112, 113, 115, 118, 120, 121, 122, 123, 124, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 141, 143, 144, 145, 148, 163, 169, 180, 182, 184, 185, 186, 191, 193, 194, 195, 196, 197, 199, 200, 202, 203, 204, 205, 206, 208, 209, 211, 213, 215, 217, 219, 221, 227, 229, 230, 237, 242, 244, 246, 250, 254, 256, 259, 279, 285, 287, 289, 294, 303, 307, 310, 315, 319, 330, 332, 344, 355, 357, 374
Cytochrome P450 Reductase, 125
Cytotoxicity, 251
Dapagliflozin, 311
Dasatinib, 61
Data Analysis, 74
Data Mining, 274
Diabetic db/db mice, 143
Diastereomers, 286
Dibetes type-II, 145
Differences in metabolism (species, gender, age, diseases), 80, 120, 131, 135, 136, 142, 146, 147, 148, 151, 155, 162, 170, 181, 217, 219, 220, 223, 258, 276, 278, 279, 296, 301, 310, 320, 329, 331, 341, 353, 359
Different sterol composition, 242
Differentiation, 214
Diltiazem, 209
Direct hydrolysis, 231
Disposition, 145, 146, 153, 154, 156, 157, 171, 223, 225, 236, 240, 247, 281, 284, 290, 300, 301, 304, 312, 316, 324, 326, 346, 348, 353, 363, 366, 369, 372, 377, 381, 382, 383, 387
DMSO, 214
Drug Design, 250
Drug Discovery, 349
Drug discovery and development, 69, 71, 76, 78, 82, 85, 86, 89, 133, 134, 136, 151, 154, 158, 159, 161, 167, 170, 173, 175, 201, 223, 226, 227, 235, 243, 245, 250, 252, 258, 265, 266, 281, 283, 287, 290, 293, 300, 302, 309, 339, 345, 352
Drug interaction, 57, 63, 71, 77, 91, 98, 101, 106, 117, 130, 135, 141, 163, 169, 174, 178, 179, 183, 184, 185, 186, 187, 188, 189, 190, 192, 193, 197, 198, 199, 201, 203, 206, 211, 226, 229, 230, 317, 338, 344, 347, 355, 368, 374, 376, 379, 381, 389
Drug Metabolizing Enzymes, 214
Ellman's assay, 231
Energy Metabolism, 260
Enzyme induction, 63, 99, 104, 123, 143, 169, 183, 185, 189, 190, 191, 192, 193, 195, 196, 198, 199, 200, 202, 215, 221, 256, 320, 355, 356, 357
Enzyme inhibition/inactivation, 57, 59, 102, 103, 106, 113, 117, 125, 130, 163, 180, 182, 184, 191, 202, 203, 205, 208, 209, 211, 224, 226, 230, 237, 276, 287, 315, 320, 347, 377, 390
ePPK, 349
ETP, 231
Extrahepatic Metabolism, 80, 94, 123, 138, 141, 165, 172, 206, 212, 213, 241, 266, 338
Fialuridine, 261
FIH, 286
Flavin-containing monooxygenase, 149
Formulation, 352
Functional Assay, 367
Gene expression and regulation, 58, 59, 64, 94, 125, 143, 144, 189, 190, 191, 193, 195, 196, 215, 216, 217, 221, 244, 252, 318, 320, 324, 329, 336, 356, 357, 360, 375, 378, 389, 390
Genomics/Metabonomics/Proteomics, 67, 131, 322
Geraniol, 207
Glucuronide Conjugates, 311
GSH Adducts, 274
GSH conjugates, 173
GST, 314
Hepatocyte Nuclear Factor-4alpha, 216, 329
Hepatocytes, 63, 88, 90, 97, 121, 151, 161, 174, 185, 191, 192, 195, 196, 197, 200, 215, 221, 222, 223, 224, 239, 240, 241, 243, 247, 248, 252, 257, 260, 278, 298, 317, 336, 359, 362, 363, 365, 382, 383
Hepatotoxicity, 253
Herbal Remedies, 106
Herbal-Drug Interaction, 178
High throughput techniques, 69, 91, 114, 122, 129, 159, 166, 168, 205, 226, 227, 228, 230, 231, 238, 266, 276, 291, 293, 302, 307, 323, 347, 376
Huh7 cells, 214
Human, 283, 311
Human Serum, 286
Idiosyncratic Adverse Reaction, 325, 328
Idiosyncratic Reactions, 96
IdMOC, 241
In Silico, 83, 87, 112, 124, 180, 186, 188, 233, 234, 235, 236, 289, 363
In Vitro, 286
In vitro techniques, 84, 87, 88, 89, 90, 91, 93, 100, 101, 103, 104, 106, 107, 114, 117, 118, 125, 146, 159, 161, 174, 175, 192, 201, 208, 212, 223, 224, 225, 226, 227, 228, 230, 237, 239, 241, 243, 245, 249, 253, 263, 291, 293, 302, 309, 321, 322, 323, 331, 336, 338, 345, 346, 356, 357, 362, 363, 365, 367, 369, 375, 376, 377, 379, 380, 383, 386, 390
Incubation medium, 222
Indolealkylamine, 187
Inhibition, 207
Inhibitors of hepatitis C virus, 170
Intermediates, 234
Intestinal metabolism, 292
Irinotecan, 333
IVIVC, 158
Ketoconazole (KTZ), 216
Lafutidine, 275
LC-MS, 74, 295
LC-MS/MS, 337
Lipid Profiling, 74
Lipophilicity, 233
Liver Microsomes, 296
Marker Substrate, 231
Mass Balance, 311
Mass Spectrometry, 229
Mechanisms of xenobiotic toxicities, 59, 60, 65, 128, 132, 133, 134, 165, 189, 190, 206, 221, 224, 249, 250, 251, 252, 256, 257, 259, 261, 276, 298, 303, 308, 315, 321, 376
Metabolic Intermediate Complex, 204
Metabolic profiling, 69, 72, 91, 94, 147, 155, 168, 170, 178, 203, 222, 242, 249, 263, 266, 299, 301, 317, 258, 268, 269, 272, 275, 278, 281, 283, 284, 285, 290, 296, 297, 300, 303, 309, 310, 311
Metabolism, 57, 64, 67, 72, 73, 78, 83, 84, 85, 87, 88, 91, 92, 94, 95, 97, 98, 99, 101, 105, 107, 108, 109, 112, 117, 118, 121, 123, 125, 126, 128, 129, 130, 133, 134, 136, 137, 140, 146, 149, 151, 155, 158, 160, 161, 162, 164, 165, 168, 172, 182, 183, 184, 186, 189, 190, 203, 206, 209, 224, 225, 228, 234, 235, 243, 246, 247, 249, 250, 251, 252, 253, 254, 256, 257, 258, 259, 260, 265, 268, 269, 275, 277, 278, 280, 281, 283, 284, 285, 293, 294, 296, 297, 298, 300, 303, 304, 306, 307, 310, 311, 312, 315, 317, 318, 321, 322, 330, 331, 332, 341, 345, 353, 377, 378, 387
Metabolite Screening, 274
Mitochondria, 121, 261
Monoterpenoids, 207
MRP, 360
Multiple Ion Monitoring, 274
Mycotoxin, 123
Myeloperoxidase, 295
Nanotechnology, 348
Nevirapine, 315
Nonmem, 349
Non-P450 phase I enzymes, 85, 121, 136, 149, 165, 202, 317, 318, 319, 320, 321, 322, 338
Nuclear magnetic resonance (NMR), 297
Nucleoside Transporters, 373
Ocular, 212
Omega-3 fatty acids, 58
OP-hydrolysis, 231
Oral pharmacokinetic Prediction, 343
Organophosphonate, 231
P450 Reaction Phenotyping, 169
PBPK Modeling, 352
Permeability, 245
Pesticides, 128
Phakellistatin 13, 337
Pharmacogenetics, 67, 68, 98, 118, 182, 217, 219, 318, 322, 323, 324, 326, 329, 330, 331, 332, 334, 335, 337, 366
Pharmacokinetics, 187
Pharmacokinetics and Pharmacodynamics, 81, 82, 89, 118, 138, 152, 153, 154, 157, 167, 188, 198, 200, 228, 266, 280, 281, 290, 326, 339, 341, 342, 343, 344, 345, 346, 347, 348, 350, 359, 369, 372, 377, 386, 390
Pinoline, 139
Plasma pooling, 168
Polymorphism, 135, 139, 327
Population PK, 349
Prasugrel, 332
Pregnancy, 144
Pregnane X receptor (PXR), 216
Primate modeling, 341
Prostate Cancer Biomarker, 107
Protein Binding, 236
Q TRAP, 274
Quantitative Microdialysis, 153
Quantitative Whole-body Autoradiography, 167
Radioactivity Detection, 72
Reactive Intermediates, 159, 164, 295
Reactive Metabolites, 96, 276, 302, 308
Receptors/nuclear receptors, 63, 65, 192, 193, 196, 197, 200, 218, 244, 307, 323, 329, 354, 356, 357, 358, 360
Reproductive Toxicity, 256
Rifampin (RIF), 216
Rosiglitazone Maleate, 344
Sandwich-culture, 240
SGLT2, 311
Soman, 231
Species-volume of distribution and mean residence time normalized method, 343
Stereoselective metabolism, 188, 211, 332, 338
Steroid Receptor Coactivator-1 (SRC-1), 216
Tacrolimus, 327
Telavancin, 155
Teratogenicity, 165
Tissue Engineering Models, 88
Tissue Repair, 260
Transporters, 61, 62, 65, 68, 94, 141, 143, 144, 145, 152, 153, 157, 174, 181, 183, 195, 218, 225, 238, 240, 242, 244, 246, 247, 253, 261, 277, 304, 367, 326, 333, 338, 384, 324, 341, 353, 360, 361, 366, 368, 370, 371, 372, 374, 375, 378, 379, 380, 381, 382, 383, 386
Triple Quadrupole-linear Ion Trap Mass Spectrometry, 274
UGT1A1, 316
Vinflunine, 202
Xanthohumol, 378