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Abstract
Biodegradation of the polyester urethane (PEU) has been performed in simulated body fluid (SBF) at 37°C for an extended period of time. Changes in physicochemical properties and toxic effects of polymer matrix as a result of degradation have been evaluated. Effect of soft segment to hard segment ratio on the degradation rate of PEU matrix has also been assessed. Biocompatibility testing of the degradation medium has been performed. This biodegradable coating may be used as coating on biomaterials, including implants as a matrix for entrapping antibiotics. Entrapped antibiotics would release in a control manner to prevent infection in biomaterials.