Effect of Polysaccharides on the Properties of the Mucoadhesive Poly(Vinyl Alcohol) Multicore–Shell Microparticles

ABSTRACT

This study discusses about the effect of polysaccharides (agar, gum tragacanth, and guar gum) on the properties of the core (organogel)–shell [poly(vinyl alcohol)] microparticles. The size, swelling, and mucoadhesive properties of the poly(vinyl alcohol) microparticles were altered in the presence of the polysaccharides. Thermal analysis confirmed the presence of organogels within the microparticles. Fourier transform infrared spectroscopy confirmed the presence of the polysaccharides within the microparticles. The microparticles were biocompatible in nature. Drug release indicated that an alteration in the shell composition can be used for altering drug release. Ciprofloxacin-loaded microparticles showed sufficient antimicrobial efficiency.

GRAPHICAL ABSTRACT

KEYWORDS:

• Agar
• core–shell microparticles
• guar gum
• gum tragacanth
• poly(vinyl alcohol)

Acknowledgments

The logistic and instrumental facilities provided by National Institute of Technology, Rourkela (NIT-R), India are hereby acknowledged.