Advanced search
Publication Cover
Polymer-Plastics Technology and Engineering Volume 55, 2016 - Issue 18
Submit an article Journal homepage
174
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Polyurethane/Polylactide-Based Electrospun Nonwovens as Carriers for Human Adipose-Derived Stromal Stem Cells and Chondrogenic Progenitor Cells

Krzysztof MaryczElectron Microscopy Laboratory, Wroclaw University of Environmental and Life Sciences, Wroclaw, Lower Silesia, PolandCorrespondence[email protected]
,
Monika MarędziakDepartment of Animal Physiology and Biostructure, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wrocław, Lower Silesia, Poland
,
Jakub GrzesiakDepartment of Biotechnology, Wroclaw Research Center EIT+, Wrocław, Lower Silesia, Poland
,
Ryszard FryczkowskiFaculty of Materials and Environmental Sciences, ATH University of Bielsko-Biala, Bielsko-Biala, Silesia, Poland
&
Jadwiga LaskaFaculty of Materials Science and Ceramics, AGH University of Science and Technology, Krakow, Lesser Poland, Poland
Pages 1897-1907 | Published online: 21 Jun 2016
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

ABSTRACT

Articular cartilage dysfunctions are major cause of pain and disability and lead to serious health complications. Cell-based therapies are proposed as treatment methods for cartilage regeneration. In this study, we proposed polyurethane/poly(L-lactide-co-D, L-lactide)-based electrospun nonwovens as carriers for the delivery of human adipose-derived stromal stem cells. We found that 6:4 and 8:2 polyurethane/poly(L-lactide-co-D, L-lactide) initially enhance proliferative rate of human adipose-derived stromal stem cells, shorten their population doubling time, promote creation of functional chondrogenic nodules during chondrogenic differentiation, improve the collagen-2-to-collagen-1 protein ratio, and upregulate the expression of collagen-2 and aggrecan genes.

GRAPHICAL ABSTRACT

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 687.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.