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Polymer-Plastics Technology and Engineering Volume 56, 2017 - Issue 2
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Original Articles

Preparation, Characterization and Assessment of the Novel Gelatin–tamarind Gum/Carboxymethyl Tamarind Gum-Based Phase-Separated Films for Skin Tissue Engineering Applications

Gauri Shankar ShawDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, India
,
Dibyajyoti BiswalDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, India
,
Anupriya BDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, India
,
Indranil BanerjeeDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, India
,
Krishna PramanikDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, India
,
Arfat AnisSABIC Polymer Research Center, Department of Chemical Engineering, King Saud University, Riyadh, Saudi Arabia
&
Kunal PalDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, IndiaCorrespondence[email protected] [email protected]
 show all
Pages 141-152 | Published online: 23 May 2016
 
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ABSTRACT

The current study delineates the development of novel gelatin–tamarind gum/carboxymethyl tamarind gum-based phase-separated films for probable skin tissue engineering applications. Polyethylene glycol was used as plasticizer. The films were characterized thoroughly using mechanical tester and impedance analyzer. Cell proliferation ability and drug release properties of the films were investigated. Mechanical studies indicated composition-dependent stress relaxation properties. Polysaccharide containing films supported better proliferation of human keratinocytes as compared to control. Drug-loaded films showed good antimicrobial properties against Escherichia coli. Analysis of the results indicated that the prepared films may be tried as matrices for skin tissue engineering.

GRAPHICAL ABSTRACT

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