Tailored Degradation and Dye Release from Poly(ester amides)

ABSTRACT

Poly(ester amides) based on L-valine and adipic acid with different aliphatic and aromatic diols were synthesized by interfacial polymerization. Four different diols such as ethylene glycol, 1,5-pentanediol, resorcinol, and catechol were used to systematically vary the chain lengths and position of the hydroxyl groups. The chemical structures, thermal properties, degradation, and dye release of these polymers were investigated. This study demonstrates that the release kinetics can be tailored through the control of the chain length of the diol and the position of the hydroxyl groups. These findings have important implications for designing biodegradable polymers for tailored release.

GRAPHICAL ABSTRACT

KEYWORDS:

• Biodegradable
• chain lengths
• cytocompatible
• dye release
• poly(ester amides)

Acknowledgments

Kaushik Chatterjee acknowledges the Ramanujan fellowship from the Department of Science and Technology (DST), India. Giridhar Madras thanks DST for the J.C. Bose fellowship. We acknowledge Ms. Queeny Dasgupta for help with DSC thermograms. We thank NMR Research Centre of IISc for access to research facilities.