ABSTRACT
In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics.
GRAPHICAL ABSTRACT
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Acknowledgment
Author is very thankful to Mr Fazal Rehman Sajid Chughtai for his kind support in the compilation of this research work and laboratory staff of Department of Pharmacy, The University of Lahore Pakistan.
Conflict of interest
All authors are agreed to submit the article and have no conflict of interest