Development, In Vitro and In Vivo Evaluation of pH Responsive β-CD-Comethacrylic Acid-Crosslinked Polymeric Microparticulate System for Solubility Enhancement of Rosuvastatin Calcium

ABSTRACT

Current research work was conducted for enhancing solubility of rosuvastatin calcium. A highly stable, biocompatible, and nontoxic β-cyclodextrin-g-poly(methacrylic acid) graft polymeric network was developed. Formulations proved entrapment efficacy (%) in between 82.30 ± 0.25 and 89.00 ± 0.25 and gel fraction between 90.34 ± 1.012 and 95.25 ± 1.331. Formulation HM2 had shown optimum swelling and drug release, i.e., 85.74% at pH 6.8. The best-fit model was first-order kinetics with anomalous diffusion as release mechanism. Likewise, solubility enhancement, i.e., 9.59-folds was determined at pH 6.8. It was concluded that hydrogel microparticles are the promising tools for improving solubility and bioavailability of hydrophobic drugs.

GRAPHICAL ABSTRACT

KEYWORDS:

• Aqueous-free radical polymerization
• hydrogel microparticles
• rosuvastatin calcium
• solubility

Additional information

Funding

Authors are thankful to Higher Education Commission of Pakistan for providing funds in the form of Indigenous Scholarship (Ref. no. 213-57857-2BM2-135).