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Experimental Aging Research
An International Journal Devoted to the Scientific Study of the Aging Process
Volume 43, 2017 - Issue 4
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Original Articles

Preliminary Evidence For The Effects Of Aging And Multiple Sclerosis On Cognitive Performance: An Analysis Based On Effect Size Estimates

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Pages 346-354 | Received 26 Jul 2016, Accepted 13 Sep 2016, Published online: 18 Jul 2017
 

ABSTRACT

Background/Study Context: Although cognitive impairment is common in persons with multiple sclerosis (MS), there are limited data on older adults with MS. The current pilot study involved a preliminary examination of cognitive impairments across a comprehensive neuropsychological assessment in older adults with MS compared with older adults without MS.

Methods: Twenty older adults with MS and 20 older adults without MS (≥60 years of age) underwent cognitive assessments, including the Trail Making Test (TMT) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The primary analytical model involved independent-samples t tests on the TMT and RBANS scores. The analysis focused on ½ SD (i.e., Cohen’s d of 0.5) for judging the differences as meaningful.

Results: Overall, the study hypotheses were supported such that older adults with MS demonstrated decreased cognitive performance that exceeded ½ SD compared with the older adults without MS.

Conclusion: This preliminary study demonstrated moderate and meaningful differences in cognitive performance in older adults with MS compared with older adults without MS. This suggests a clear need for identifying strategies for alleviating cognitive impairment in older adults with MS.

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