Comparison of methods for analyzing binary repeated measures data: A simulation-based study (comparison of methods for binary repeated measures)

ABSTRACT

In this study, some methods suggested for binary repeated measures, namely, Weighted Least Squares (WLS), Generalized Estimating Equations (GEE), and Generalized Linear Mixed Models (GLMM) are compared with respect to power, type 1 error, and properties of estimates. The results indicate that with adequate sample size, no missing data, the only covariate being time effect, and a relatively limited number of time points, the WLS method performs well. The GEE approach performs well only for large sample sizes. The GLMM method is satisfactory with respect to type I error, but its estimates have poorer properties than the other methods.

KEYWORDS:

• Binary Repeated Measures (BRM)
• Generalized Estimating Equation (GEE)
• Generalized Linear Mixed Models (GLMMs)
• SAS
• Simulation Study
• Weighted Least Squares (WLS)

MATHEMATICS SUBJECT CLASSIFICATION:

• 62M07
• 62M09